Astros (15-11) fall to the San Diego, 4-3, halting its best winning streak of the season at eight consecutive games since returning to baseball post-Covid-19.
Lance McCullers took the loss, giving up four runs and seven hits in five innings.
San Diego (16-12) kept its streak alive, improving to five consecutive victories.
Javy Guerra picked up his first win, and Emilio Pagán collected his first save as a Padre.
The Rockets will be seeking its third straight victory on Saturday when it meets Oklahoma in game three of the NBA Playoffs.
The Mavericks lost to the Los Angelas Clippers, 130-122, in game three of the NBA playoffs, now trailing two games to one.
The loss of top player Luka Doncic to a sprained ankle in the third quarter proved to be pivotal.
Kawhi Leonard led the Clippers with 36 points on 13-24 shooting. Game four is Saturday at 2:30 PM.
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